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KMID : 0608520060120010103
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Korean Journal of Oriental Medicine
2006 Volume.12 No. 1 p.103 ~ p.109
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Effect of Hovenia dulcis on liver protection in SD male rats treated with CCl₄
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Ma Jin-Yeul
Kim Sang-Woong
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Abstract
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We investigated liver protection effect of the Hovenia dulcis Thunb extraction which has treated with carbon tetrachloride (CCl₄, 1.0 ml/㎏) in SD male rat (20 weeks). We observed the amount of leukocyte, erythrocyte, hemoblobin and hematocrit are increased and the number of plaque is decreased for treatment of CCl₄, However, after treatment of Hovenia dulcis Thunb extraction(15 mL/㎏), we have same result that of control group which has treated with CCl₄. The blood biological data showed that the value of AST (Aspartate aminotransferase), ALT (Alanine aminotransferase) and LDH (Lactate dehydronase) are increased significantly for the negative control group compared to that of control group. For experimental group, increased gap for AST, ALT and LDH is decreased about 50% compared to that of the negative control group, respectively, In addition, it was confirmed that the recovery effect of a mysterious death of an interstitial cell of the experimental group is to be compared to that of the negative control group for a sample of pathological tissue.
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KEYWORD
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Hovenia dulcis Thunb, CCl₄, Blood Biochemistry, Liver Tissue
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